Stephanie Elizabeth Mohr

The paper identifies genes involved in octanoic acid resistance by combining experimental evolution and CRISPR screens in Drosophila species.

DIOPT updates its ortholog prediction tool to include more species and algorithms, enhancing its utility for cross-species genomic analysis.

The paper develops a genome-wide CRISPR-Cas9 knockout screening platform for Ixodes scapularis ticks and identifies genes associated with cellular fitness and drug resistance.

The paper identifies Attractin as the receptor for Nigritoxin, a Vibrio toxin, and shows that related toxins use this receptor but have distinct effector domains.

The paper introduces IntAC, a CRISPR screening method for Drosophila cells that improves accuracy by suppressing early Cas9 activity, leading to a more comprehensive list of fitness genes.

CESA identifies potential phospho-specific antibodies from mammalian collections that could be useful for detecting phosphorylated proteins in Drosophila and other species.

This study introduces a phage-displayed synthetic library for nanobody discovery and validates it by screening against Drosophila secreted proteins, demonstrating its utility for immunological applications.

The paper uses a genome-wide CRISPR screen in Anopheles mosquito cells to identify essential genes and factors involved in clodronate liposome function.

This paper demonstrates genetic modification of a tick cell line using CRISPR-Cas9 and ectopic expression, showing increased infection by Anaplasma phagocytophilum after disrupting the IMD pathway.

A Local Interaction Score (LIS), computed from AlphaFold-Multimer predicted aligned error, separates curated fly and human protein interactions from controls better than ipTM, recovering small or flexible interfaces.

The paper develops a pooled CRISPR activation screening platform in Drosophila cells to identify rapamycin resistance genes, finding three novel genes involved in RTK-Akt-mTOR pathway activation.

PANGEA is a new GSEA tool that allows flexible analysis of gene sets using various annotations, enhancing visualization and comparison of results for Drosophila and other organisms.

The paper identifies DPM1 as a therapeutic target for DPAGT1-CDG by showing its inhibition rescues ER stress and glycoprotein levels in Drosophila models.

The paper introduces two short NanoTag epitopes and their nanobodies for in vivo protein visualization and manipulation in Drosophila, demonstrating their utility in multiple assays and CRISPR-based tagging.

Paralog Explorer identifies candidate paralogs in model organisms and provides tools for their functional analysis.

The paper develops bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquito cell lines to study gene function and disease control.

DRscDB provides a database for comparing scRNA-seq data across species, enabling searches for orthologous genes and cell type-specific expression patterns.

BioLitMine helps researchers find relevant biomedical literature by leveraging MeSH terms and gene annotations to improve search accuracy and identify co-cited genes and authors.

The paper updates TRiP's RNAi and CRISPR fly stocks, presenting over 5,000 CRISPR-OE and -KO stocks for gene activation and knockout studies in Drosophila.

SNP-CRISPR is a web tool that designs CRISPR sgRNAs for SNP-containing alleles, accounting for genetic variations in non-reference genomes and across genetic backgrounds.

The paper introduces three simplified CRISPR-based methods for DNA insertion in Drosophila, using short homology arms and ssDNA/dsDNA donors to generate transgenic constructs efficiently.

The paper identifies genes involved in zinc detoxification in Drosophila cells through functional genomics and transcriptomics analyses, revealing key pathways and human disease-related gene orthologs.

Gene2Function integrates functional information of conserved genes across species into an online resource to aid in gene function discovery.