GABA/Glutamate neuron differentiation imbalance and increased AKT/mTOR signalling in CNTNAP2-/-cerebral organoids.
Kleanthi Chalkiadaki, Elpida Statoulla, Maria Zafeiri, Georgia Voudouri, Theoklitos Amvrosiadis, Alexandra Typou, Niki Theodoridou, Dimitrios Moschovas, Apostolos Avgeropoulos, Martina K. Samiotaki, John O. Mason, Christos G. Gkogkas
This study uses cerebral organoids to show that CNTNAP2 loss causes imbalanced GABA/glutamate neuron differentiation and increased AKT/mTOR signaling, linked to ASD pathophysiology.
Biological Psychiatry Global Open Science · Nov 8, 2024Peer-reviewedNeuroscience