Kleanthi Chalkiadaki

This study shows that SNCA triplication in human midbrain organoids causes early proteostasis disruption and extracellular matrix changes before neurodegeneration.

This study uses cerebral organoids to show that CNTNAP2 loss causes imbalanced GABA/glutamate neuron differentiation and increased AKT/mTOR signaling, linked to ASD pathophysiology.

The paper identifies mRNA sequences that stall ribosomes in neurons, linking these sequences to FMRP association and stalled polysome function.

This study shows that eIF4E phosphorylation is essential for maintaining dentate gyrus LTP in vivo by recruiting β-catenin to the mRNA cap and enhancing Wnt pathway translation.

This study develops a MAM mouse model of schizophrenia and finds sex-specific cognitive and neurophysiological deficits in male but not female mice.