Christos G. Gkogkas

Codon-dependent regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins

This study identifies ZC3H7A and ZC3H7B as RNA-binding proteins that regulate mRNA stability and translation by targeting non-optimal A/U3 codons.

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

This study shows that translational control in spinal cord neurons, particularly in inhibitory and PV+ interneurons, significantly influences gene expression and pain hypersensitivity during the chronic phase of neuropathic pain.

SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids

This study shows that SNCA triplication in human midbrain organoids causes early proteostasis disruption and extracellular matrix changes before neurodegeneration.

GABA/Glutamate neuron differentiation imbalance and increased AKT/mTOR signalling in CNTNAP2-/-cerebral organoids.

This study uses cerebral organoids to show that CNTNAP2 loss causes imbalanced GABA/glutamate neuron differentiation and increased AKT/mTOR signaling, linked to ASD pathophysiology.

Ribosomes in RNA granules are stalled on mRNA sequences that are consensus sites for FMRP association.

The paper identifies mRNA sequences that stall ribosomes in neurons, linking these sequences to FMRP association and stalled polysome function.

eIF4E phosphorylation recruits β-catenin to mRNA cap and selectively promotes Wnt pathway translation in dentate gyrus LTP maintenance in vivo

This study shows that eIF4E phosphorylation is essential for maintaining dentate gyrus LTP in vivo by recruiting β-catenin to the mRNA cap and enhancing Wnt pathway translation.

Induction of an alternative 5’ leader enhances translation of Inpp5e and resistance to oncolytic virus infection

The paper identifies an alternative 5' leader in Inpp5e mRNA that enhances translation and confers resistance to oncolytic virus infection in cancer cells.