John O. Mason

This study shows that PAX6 deficiency in human cerebral organoids leads to an increased inhibitory neuron population and altered excitatory/inhibitory ratio due to dysregulated PTN-PTPRZ1 signaling.

Embedding day-8 cerebral organoids in Geltrex loaded with human brain microvascular endothelial cells, plus VEGF-supplemented mixed media, yields integrated endothelial networks and almost three-fold less apoptosis.

This study uses cerebral organoids to show that CNTNAP2 loss causes imbalanced GABA/glutamate neuron differentiation and increased AKT/mTOR signaling, linked to ASD pathophysiology.

This study compares phenotypes of Pax6 mutant cerebral organoids with Pax6 mutant mouse embryos, finding similarities in neural differentiation and cell cycle changes.

This study shows that Pax6 limits the competence of developing cortical progenitors to respond to morphogens, preventing inappropriate lineage generation.

This study shows that E2A drives neural differentiation in pluripotent mouse cells by activating neural lineage genes and repressing Nodal signalling.

The paper shows Pax6 has opposite effects on proliferation-differentiation balance in murine diencephalon and cortex, with Foxg1 mediating these differences.