Nikki K. Lytle

The paper compares primary and liver PDAC lesions using single-cell transcriptomics to identify MET as a target in pancreatic cancer metastasis.

This paper identifies allele-specific resistance mechanisms to daraxonrasib in pancreatic cancer and demonstrates how these guide effective salvage therapies.

The paper maps the molecular programs enabling basal-to-luminal fate switching in mammary epithelial cells using time-resolved single-cell epigenetic and transcriptomic analyses.