Andreas Lossius

GATHeR reconstructs full-length, paired B-cell receptor sequences from scRNA-seq data, improving subclass, allele, and isoform resolution, especially in naive and memory B cells.

The paper develops MS-BCR-DB, a unified BCR repertoire database for MS, identifying disease-associated features and shared clonotypes across patients.

The paper identifies putative antigen targets of a stereotyped intrathecal B cell response in multiple sclerosis by generating monoclonal antibodies and using IPMS/MS to screen against proteins.

The paper develops a bioinformatic workflow to identify functional roles of less-understood proteins by analyzing scRNA-seq data, applying it to SH2D2A and linking it to T-T synapses enriched for ITGB2.

The paper identifies SH2D2A as a favourable prognosis marker in bladder cancer, enriched in Treg cells, and suggests its role in immunotherapy targets.

The paper introduces a method using ultra-long sequencing and bioinformatics to resolve haplotypes in the human immunoglobulin heavy chain locus, uncovering novel alleles and structural variants.