Author

Upeksha C. Dissanayake

The University of Texas at DallasORCID 0000-0002-6991-3452Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Andrew J. FisheriD· 1 shared Carlos H. Trasviña‐ArenasiD· 1 shared Gerardo Andrés CisnerosiD· 1 shared Martin P. HorvathiD· 1 shared Merve DemiriD· 1 shared Mohammad Hashemian· 1 shared Nallely Hoyos-Gonzalez· 1 shared Nikole Tamayo· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Andrew J. FisherORCID

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1 paper

Recent·Most cited

Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its cluster cofactor and active site required for DNA repair

Carlos H. Trasviña‐Arenas, Upeksha C. Dissanayake, Nikole Tamayo, Mohammad Hashemian, Wen-Jen Lin, Merve Demir, Nallely Hoyos-Gonzalez, Andrew J. Fisher, Gerardo Andrés Cisneros, Martin P. Horvath, Sheila S. David

The paper investigates the role of the [4Fe-4S] cofactor in MUTYH DNA repair by analyzing cancer variants and solving the enzyme's crystal structure.

Nature Communications · Apr 15, 2025Peer-reviewedBiochemistry