BiochemistryNature CommunicationsPeer-reviewed
Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its cluster cofactor and active site required for DNA repair
Carlos H. Trasviña‐Arenas, Upeksha C. Dissanayake, Nikole Tamayo…·Sheila S. David
The paper investigates the role of the [4Fe-4S] cofactor in MUTYH DNA repair by analyzing cancer variants and solving the enzyme's crystal structure.
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