Emily S. W. Wong

This study identifies age-acquired enhancers in mouse hearts and shows that exercise can reverse their activation.

The paper identifies MDFIC2 as a PIEZO channel auxiliary subunit specifically expressed in mechanosensitive neurons and shows it modulates PIEZO1/2 mechanosensitivity and inactivation kinetics.

The paper develops a workflow for isolating and profiling adult teleost cardiac cells, revealing exercise-induced hypertrophy and hyperplasia and defining proteo-transcriptomic regulatory networks.

ASPEN improves detection of allelic dynamics in single-cell RNA-seq by modeling mean and variance, revealing patterns of allelic imbalance and variance in mouse cells.

The paper develops a mouse cortical organoid platform to study cis-regulatory evolution and identifies genes with dynamic allelic imbalances during neurogenesis.

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

DNA-Diffusion uses diffusion models to generate cell type-specific regulatory DNA sequences that modulate chromatin accessibility and gene expression.

This study shows that Decitabine suppresses tumour growth in ER+ breast cancer by inducing DNA hypomethylation and altering 3D chromatin structure.

The paper introduces BOM, a computational model that captures cell-type-specific regulatory information in distal sequences by analyzing TF binding motifs, showing it outperforms deep learning models with fewer parameters.

This study identifies genetic and molecular factors underlying atrial septal defects in mice using QTL mapping and transcriptome analysis, revealing complex networks and non-coding variants involved.

The paper identifies cell-type-specific regulatory roles of a heptad of transcription factors in human hematopoietic stem and progenitor cells.

The paper identifies a link between the emergence of new enhancers and late DNA replication regions in mammals, showing increased tissue specificity and TF binding in these regions.

The paper identifies conserved chromatin regulatory features in sponge embryogenesis, including distal enhancers and silencers, through chromatin accessibility profiling.

The paper quantifies how cis-acting genetic variation affects chromatin accessibility, histone modifications, and gene expression in Drosophila embryos, finding that much of this variation does not propagate to gene expression.

The paper maps cardiac differentiation at single-cell resolution, identifies HOPX dysregulation, and shows hypertrophic signaling is required for HOPX transcription in hPSC-derived cardiomyocytes.

The paper generates a transcriptome resource and eQTL catalogue in vervet monkeys, revealing sex and age-related expression patterns and key regulatory loci.

The paper investigates cis and trans mechanisms influencing transcription factor binding and gene expression evolution in mice by analyzing allele-specific occupancy in crosses of two inbred strains.