Dendritic cell PD-L2 restrains intratumoral CD8+ T cell immunity
Jinwoo Nah, Amanda Sun, Anushka Yadav, Adina Scheinfeld, Tamjeed Azad, Samuel A. Rose, Burkhard Becher, James William Smithy, Michael Andrew Postow, Charlotte Eielson Ariyan, Yuri Pritykin, Chrysothemis C. Brown
This study identifies PD-L2's role on dendritic cells in restraining CD8+ T cell immunity in tumors, showing distinct functions from PD-L1 and suggesting therapeutic implications for PD-L2 blockade.
bioRxiv · Sep 16, 2026 · PreprintImmunology