A Novel Biofilm Amyloid Ligand for Caspase-11 Drives Hyperactivation in Dendritic Cells
Shrutika Mintri, Guangnan Hu, Anukriti Mathur, Leah M. Whiteman, Alexandre Dinis, Brian Le, Kaitlyn C. M. Grando, Patience Shumba, Vijay A. K. Rathinam, Egil Lien, Çağla Tükel, Katherine A. Fitzgerald, Stefania Gallucci
This paper identifies curli amyloid as a novel activator of the non-canonical inflammasome in dendritic cells, driving hyperactivation without pyroptosis.
bioRxiv · Oct 4, 2026 · PreprintImmunology