Katherine A. Fitzgerald

This paper identifies curli amyloid as a novel activator of the non-canonical inflammasome in dendritic cells, driving hyperactivation without pyroptosis.

This study shows that keratinocytes produce IFN-kappa constitutively to protect human skin against RNA and DNA viruses through distinct antiviral mechanisms.

This study identifies CNBP's role in regulating the IL12β-IFN-γ axis during Plasmodium infection, showing its importance in immune control and potential as a therapeutic target.

This study shows that endothelial cells with a STINGV154M mutation cause persistent skin inflammation after UVB exposure, linking STING activation to impaired myeloid cell recruitment and delayed inflammation resolution.

This study identifies an alternative cGAS signaling pathway independent of cGAMP that promotes neutrophil recruitment and viral dissemination in herpes simplex encephalitis.

This study identifies Raver1 as a regulator of Ripk1 RNA splicing, which affects caspase-8-mediated pyroptosis, inflammation, and resistance to Yersinia infection.

This paper uses CRISPR to test host factors affecting influenza A virus infection, finding that CMAS knockout and B4GALNT2 overexpression restrict IAV, while ADAR1 overexpression has a pro-viral effect on CVB.

Flnc improves lncRNA identification from RNA-seq data by using machine learning, achieving over 85% accuracy without requiring H3K4me3 profiles.

This study identifies CNBP as a regulator of c-Rel dependent IL-12β gene transcription and Th1 immunity, showing its role in macrophage function and resistance to toxoplasmosis.