This study identifies two genetic regions associated with astrovirus diarrhea susceptibility in Bangladeshi infants through a genome-wide association study.

Open Forum Infectious Diseases · Feb 29, 2024Peer-reviewedGenetic & Genomic Medicine

Targeting hepatitis B vaccine escape using immunogenetics in Bangladeshi infants

Guillaume Butler‐Laporte, Kathryn Auckland, Zannatun Noor, Mamun Kabir, Masud Alam, Tommy Carstensen, Genevieve L. Wojcik, Amanda Yoon-Yee Chong, Cristina Pomilla, Janelle Annette Noble, Shana L. McDevitt, Gaby P. Smits, Susan Wareing, Fiona R.M. van der Klis, Katie JM Jeffery, , Alexander J. Mentzer

The paper identifies HLA variants associated with HBV vaccine response in Bangladeshi infants and links them to vaccine escape mechanisms.

medRxiv · Jun 26, 2023 · PreprintGenetic & Genomic Medicine

Genome-wide association study of cryptosporidiosis in infants implicates PRKCA

Genevieve L. Wojcik, Poonum S. Korpe, Chelsea S. Marie, Alexander J. Mentzer, Tommy Carstensen, Josyf C. Mychaleckyj, Beth D. Kirkpatrick, Stephen S. Rich, PATRICK J. CONCANNON, Abu Syed Golam Faruque, Rashidul Haque, William A. Petri, Priya Duggal

This paper conducts a GWAS to identify genetic variants associated with symptomatic cryptosporidiosis in infants, finding a strong association with an intronic SNP in PRKCA.

mBio · Feb 3, 2020Peer-reviewedGenetics

Genome-Wide Association Study Reveals Genetic Link Between Diarrhea-Associated Entamoeba histolytica Infection And Inflammatory Bowel Disease

Genevieve L. Wojcik, Chelsea S. Marie, Mayuresh M. Abhyankar, Nobuya Yoshida, Kôji Watanabe, Alexander J. Mentzer, Tommy Carstensen, Josyf C. Mychaleckyj, Beth D. Kirkpatrick, Stephen S. Rich, PATRICK J. CONCANNON, Rashidul Haque, George C. Tsokos, William A. Petri, Priya Duggal

This study identifies genetic variants associated with Entamoeba histolytica infection and links them to inflammatory bowel disease susceptibility.

mBio · Sep 18, 2018Peer-reviewedGenetics