This study identifies two genetic regions associated with astrovirus diarrhea susceptibility in Bangladeshi infants through a genome-wide association study.

Open Forum Infectious Diseases · Feb 29, 2024Peer-reviewedGenetic & Genomic Medicine

Genome-wide association study of cryptosporidiosis in infants implicates PRKCA

Genevieve L. Wojcik, Poonum S. Korpe, Chelsea S. Marie, Alexander J. Mentzer, Tommy Carstensen, Josyf C. Mychaleckyj, Beth D. Kirkpatrick, Stephen S. Rich, PATRICK J. CONCANNON, Abu Syed Golam Faruque, Rashidul Haque, William A. Petri, Priya Duggal

This paper conducts a GWAS to identify genetic variants associated with symptomatic cryptosporidiosis in infants, finding a strong association with an intronic SNP in PRKCA.

mBio · Feb 3, 2020Peer-reviewedGenetics

Household Transmission Study of Cryptosporidiosis in Bangladesh

Poonum S. Korpe, Carol Gilchrist, Cecelia Burkey, Emtiaz Ahmed, Vikram Madan, Rachel Castillo, Shahnawaz Ahmed, Tuhinur Arju, Masud Alam, Mamun Kabir, William A. Petri, Rashidul Haque, A.S.G. Faruque, Priya Duggal

This study investigates household transmission of Cryptosporidium in Bangladesh, finding higher secondary infection rates in urban areas compared to rural regions.

bioRxiv · Feb 23, 2018 · PreprintMicrobiology