Neal Ian Lindeman

This study uses spatial imaging to identify architectural changes in bone marrow that predict disease activity and response to therapy in myelodysplastic neoplasms.

EXaCT-2 is a whole exome sequencing platform that detects various cancer-related genomic features with high accuracy and sensitivity, outperforming standard assays in detecting sub-clonal mutations and molecular metrics.

The paper provides a pan-cancer spatial analysis of immune biomarkers in the tumor microenvironment using multiplex immunofluorescence data from 2,019 tumors across 14 cancer types.

This study analyzes genomic alterations in a large IBC cohort, finding high TP53 mutation frequency and NOTCH pathway enrichment, but no major genomic differences compared to non-IBC cases.

This paper evaluates computational methods to infer germline vs. somatic variants from tumor-only sequencing data using 1,608 patients and compares results to germline testing.