Madhu Micheal Ouseph

Spatial remodeling of bone marrow architecture defines tissue-state signatures of disease activity and therapeutic response in myelodysplastic neoplasms

This study uses spatial imaging to identify architectural changes in bone marrow that predict disease activity and response to therapy in myelodysplastic neoplasms.

EXaCT-2: An augmented and customizable oncology-focused whole exome sequencing platform

EXaCT-2 is a whole exome sequencing platform that detects various cancer-related genomic features with high accuracy and sensitivity, outperforming standard assays in detecting sub-clonal mutations and molecular metrics.

A Single Trophoblast Layer Acts as the Gatekeeper at the Endothelial-Hematopoietic Crossroad in the Placenta

The paper shows that parietal trophoblast giant cells regulate hematopoietic stem cell development in the placenta through paracrine signaling.