Author

Weiwei Li

Chinese Academy of SciencesORCID 0000-0002-7108-5625Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Weiwei Li4 papers · Max Planck Institute of Animal Behavior

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:protein design· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Assay:DNA methylation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Jianxun QiiD· 3 shared Chang Xu· 2 shared Hanyi Liao· 2 shared Huijun Zhang· 2 shared Lifeng Fu· 2 shared Qiyue Wang· 2 shared Yang LiiD· 2 shared Chao ZhangiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

Jianxun QiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural Insights into Single-Stranded DNA Recognition and Modified Substrate Tolerance in an Engineered Terminal Deoxynucleotidyl Transferase

Yang Li, Hanyi Liao, Qiyue Wang, Weiwei Li, Chang Xu, Jianxun Qi, Huijun Zhang, Lifeng Fu, Meng Yang

This paper presents the crystal structure of an engineered TdT variant and shows how mutations alter substrate specificity to accommodate bulky DNA terminators.

bioRxiv · Dec 26, 2025 · PreprintBiochemistry

Structural Mechanism of Specific Nucleobase Recognition by a Monoclonal Antibody in CoolMPSTM Sequencing

Yang Li, Qiyue Wang, Hanyi Liao, Weiwei Li, Chang Xu, Jianxun Qi, Huijun Zhang, Lifeng Fu, Meng Yang

This paper reports the crystal structures of an antibody used in CoolMPS sequencing, revealing the structural basis for its high specificity in recognizing modified nucleotides.

bioRxiv · Dec 23, 2025 · PreprintBiochemistry

Designing a broad-spectrum four-helix bundle targeting different strains of SARS-CoV-2 Spike Receptor Binding Domains with ACE2-like binding interface

Qinghui Nie, Hongmei Yin, Ke Chen, Chao Zhang, Weiwei Li, Jianxun Qi, Jinle Tang, John Z. H. Zhang, Jian Zhan, Yaoqi Zhou

The paper designs a protein that binds to multiple SARS-CoV-2 RBD variants with high affinity, demonstrating a strategy for broad-spectrum antiviral inhibitors.

bioRxiv · Jun 4, 2025 · PreprintMolecular Biology