Jurrien Dean

RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation

This study identifies DIS3 as a regulator of Pou6f1 mRNA degradation, which is critical for mouse pre-implantation cell differentiation and blastocyst formation.

Germ-cell specific eIF4E1B regulates maternal RNA translation to ensure zygotic genome activation

The paper shows that eIF4E1B regulates maternal mRNA translation to enable zygotic genome activation by protecting chromatin remodeling and reprogramming factor mRNAs from degradation.

Persistent pervasive transcription in RNA exosome depleted oocytes results in loss of female fertility

This study shows that depletion of Dis3 in oocytes leads to persistent transcription and fertility loss due to disrupted RNA processing and epigenetic changes.

Sperm acrosome overgrowth and infertility in mice lacking chromosome 18 pachytene piRNA

This study shows that loss of pachytene piRNAs on chromosome 18 in mice causes sperm head abnormalities, infertility, and defects in acrosome formation and function.

EXOSC10 sculpts the transcriptome during the growth-to-maturation transition in mouse oocytes

This study identifies EXOSC10 as a key regulator of the transcriptome during the growth-to-maturation transition in mouse oocytes, showing its role in RNA degradation and oocyte quality.

Oocytes, a single cell and a tissue

The paper compares single and pooled mouse oocyte RNA-seq datasets, showing higher reproducibility with single oocyte sequencing and proposes external spike-ins for normalization across developmental stages.