Di Wu

WHaloForce is a chemigenetic tension sensor that enables quantitative imaging of molecular forces in living cells and animals, revealing distinct force patterns in different tissues.

IMMClock predicts immune age of T cells and NK cells using gene expression, showing immune aging is more linked to cellular aging than differentiation and is accelerated in diseases.

This study identifies DIS3 as a regulator of Pou6f1 mRNA degradation, which is critical for mouse pre-implantation cell differentiation and blastocyst formation.

The paper shows that eIF4E1B regulates maternal mRNA translation to enable zygotic genome activation by protecting chromatin remodeling and reprogramming factor mRNAs from degradation.

This study shows that depletion of Dis3 in oocytes leads to persistent transcription and fertility loss due to disrupted RNA processing and epigenetic changes.

This study identifies EXOSC10 as a key regulator of the transcriptome during the growth-to-maturation transition in mouse oocytes, showing its role in RNA degradation and oocyte quality.

The paper compares single and pooled mouse oocyte RNA-seq datasets, showing higher reproducibility with single oocyte sequencing and proposes external spike-ins for normalization across developmental stages.