NeurosciencebioRxivPreprint
A painless nerve growth factor variant uncouples nociceptive and neurotrophic TrkA signaling
Shailesh Kumar, Harry Jung, Gerard Walker…·Moitrayee Bhattacharyya
This paper identifies a NGF variant that selectively biases TrkA signaling towards neurotrophic functions without triggering pain, revealing mechanisms for therapeutic targeting of the NGF-TrkA pathway.
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