Jaimin K. Rana

The paper determines the structure of tau filaments in Alzheimer's disease patients with co-morbid LATE-NC using cryo-electron microscopy, revealing a CTE-type tau fold in addition to the Alzheimer's fold.

This study presents the cryo-EM structure of human TWIK-2 and identifies key residues and modulators, providing a foundation for developing anti-inflammatory therapeutics.

This paper identifies a NGF variant that selectively biases TrkA signaling towards neurotrophic functions without triggering pain, revealing mechanisms for therapeutic targeting of the NGF-TrkA pathway.

This study uses in situ cryo-ET to show HPV remains intact during retrograde transport and lysosome residency, challenging existing models of viral disassembly and transport.

The paper reports the crystal structure of the THEMIS CABIT2 domain, revealing a novel fold with an inserted SH3-like domain and insights into its interaction with GRB2.