Antonino Cattaneo

Mapping and longitudinal imaging of potentiated synapses in the mouse hippocampus using SynActive-eGRASP

The paper develops SA-eGRASP to map and track potentiated synapses in the mouse hippocampus following learning and uses it to study long-term synaptic dynamics.

The PSD-95 interactome of hippocampal synapses potentiated in response to an in vivo learning task

The paper characterizes the PSD-95 interactome of hippocampal synapses potentiated by an in vivo learning task using a genetically encoded probe and mass spectrometry.

The mutational landscape of innervation axes in cancer

This study analyzes mutations in neural signaling pathways across cancers, finding 65% of patients have alterations linked to poor survival and complex pathway interactions.

Loss of microglia reduces NGF signaling and retinal ganglion cell survival

This study shows that microglia are essential for NGF/TrkA signaling and neuroprotection in the retina, as their depletion leads to reduced NGF signaling and retinal ganglion cell loss.

Distinct spatial distribution of potentiated dendritic spines in encoding- and recall-activated hippocampal neurons

The paper shows that potentiated dendritic spines in hippocampal neurons are spatially distributed differently during memory encoding and recall phases.

A painless nerve growth factor variant uncouples nociceptive and neurotrophic TrkA signaling

This paper identifies a NGF variant that selectively biases TrkA signaling towards neurotrophic functions without triggering pain, revealing mechanisms for therapeutic targeting of the NGF-TrkA pathway.

Tau alters global gene expression affecting chromatin in the early stages of Alzheimer's disease

The paper shows that Tau affects global gene expression and chromatin structure in early Alzheimer's disease stages through cellular and transcriptomic analysis.

SARS-CoV-2 infection leads to Tau pathological signature in neurons

This study shows that SARS-CoV-2 infection causes Tau phosphorylation and aggregation in neurons, linked to Alzheimer's disease pathology.

Nuclear Tau modulates VGluT1 expression: a new function for Tau

The paper shows that nuclear Tau regulates VGluT1 expression, linking Tau's non-canonical function to glutamatergic synaptic transmission and neurodegeneration.

A congenital pain insensitivity mutation in the nerve growth factor gene uncouples nociception from affective pain in heterozygous humans and mice

This study investigates how congenital pain insensitivity in heterozygous humans and mice affects affective pain responses, finding dissociated effects on learned fear and neural processing.

Assessment of Antibody Library Diversity through Next Generation Sequencing and Technical Error Compensation.

This paper introduces a PCR-free NGS approach and software (DEAL) to accurately estimate antibody library diversity by accounting for sequencing errors.

Activity-dependent expression of reporter proteins at dendritic spines for synaptic activity mapping and optogenetic stimulation

The paper introduces a method to express light-sensitive proteins at active dendritic spines to map and stimulate synaptic activity.