Moitrayee Bhattacharyya

Two-Step Mechanism of Bruton's Tyrosine Kinase MembraneRecruitment and Activation

This paper uses native mass spectrometry to show BTK recruits to membranes via phosphatidylserine and is activated by PIP3, proposing a two-step mechanism for membrane recruitment and activation.

A painless nerve growth factor variant uncouples nociceptive and neurotrophic TrkA signaling

This paper identifies a NGF variant that selectively biases TrkA signaling towards neurotrophic functions without triggering pain, revealing mechanisms for therapeutic targeting of the NGF-TrkA pathway.

Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition

This study shows PI3K promotes resistance to KRAS inhibition in PDAC by activating wild-type RAS signaling through GAB1 recruitment and MAPK activation.

Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging

This study shows that DNA hydroxymethylation in gene bodies limits transcriptional changes with age in mouse and human tissues.

Breakage of the Oligomeric CaMKII Hub by the Regulatory Segment of the Kinase

The paper shows that the regulatory segment of CaMKII can break the oligomeric hub into smaller assemblies through binding and structural destabilization.

Hierarchical organization endows the kinase domain with regulatory plasticity

This study reveals a hierarchical organization in the kinase domain that enables regulatory plasticity through distinct functional units.