Xinyi Zhang

This paper introduces a benchmark to evaluate single-cell drug perturbation models by assessing their fidelity to drug-response signatures, finding that expression similarity is a poor proxy for mechanism preservation.

This study shows that SIRT5 desuccinylates GLS and GDH, reducing their activity and attenuating ammonia-induced autophagy in MAC-T cells.

This study uses snRNA-seq to identify type C low-threshold mechanoreceptors as key contributors to paclitaxel-induced neuropathic pain.