Sebastian Grönke

The paper identifies a Wolbachia protein that enhances Drosophila resistance to virus infection via the IMD pathway.

This study shows that DNA-binding-independent mechanisms contribute to dFOXO's role in metabolic regulation in Drosophila, as evidenced by altered lipid mobilization and transcriptional changes in metabolic and chromatin regulators during starvation.

This study shows that combining trametinib and rapamycin extends mouse lifespan more than either drug alone and improves health markers in older age.

This study shows that enhancing autophagy through redox regulation extends lifespan in Drosophila by highlighting the role of a specific cysteine residue in Atg4a.

This study shows that inhibiting S6K in Drosophila and mice reduces age-related inflammation and extends lifespan through the endolysosomal system and immune pathways.

This study identifies molecular foci of brain aging in mice using spatiotemporal RNA-seq, showing accelerated glial aging in white matter and differential gene expression linked to neurodegenerative diseases.

This study identifies aging-associated increases in transcriptional elongation speed across multiple species and shows that reducing this speed extends lifespan.

This study identifies male-specific brain aging improvements from reduced neuronal insulin signaling in mice.

The paper identifies the one carbon folate cycle as a shared metabolic mechanism regulating longevity across species.