Author

Aleksander M. Gontarczyk

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:scRNA-seq· 4 Research Focus:variant effect prediction· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Andrew Roger BassettiD· 3 shared Geraldine RodschinkaiD· 2 shared Magdalena E StraußiD· 2 shared Mathew J. GarnettiD· 2 shared Sarah CooperiD· 2 shared Shikha KatariaiD· 2 shared Valentina MiglioriiD· 2 shared Adib Miraki FeriziD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersGenomics

Andrew Roger BassettORCID

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Author profile →

4 papers

Recent·Most cited

Transcriptomic and phenotypic characterization of Alzheimer's disease risk genes in neurons and astrocytes highlights shared and cell type specific cellular mechanisms

Caia S. Dominicus, Diego Peretti, Geraldine Rodschinka, Samuel Ogden, Juliette Steer, Melissa Leija‐Salazar, Adib Miraki Feriz, Claudia Feng, Shikha Kataria, Jing Su, Aleksander M. Gontarczyk, Valentina Migliori, Lewis Evans, Mo Lotfollahi, Leopold Parts, , Andrew Roger Bassett

The paper uses single-cell transcriptomics and phenotypic analysis of gene knockouts in hiPSC-derived neurons and astrocytes to identify cell-type specific and shared mechanisms of Alzheimer's disease risk genes.

bioRxiv · Oct 14, 2026 · PreprintGenomics

STEER-seq: a recombinase based platform for pooled multimodal single-cell perturbation screening

Valentina Migliori, Chenqu Suo, Olli Dufva, Ivan Gyulev, Krzysztof Polański, Vasiliki Symeonidou, Geraldine Rodschinka, Ioannis Sarropoulos, Sho Iwama, Alexander S. Steemers, Aleksander M. Gontarczyk, Hayden Powell, Ana-Maria Cujba, Jong-Eun Sebastiaan Park, Mathew J. Garnett, , Andrew R Bassett

STEER-seq enables pooled single-cell perturbation screening in hiPSCs by using defined genomic integration and barcode tracking to study transcription factor effects on cell identity.

bioRxiv · Oct 9, 2026 · PreprintGenomics

Saturation-seq integrates single-cell saturation genome editing and RNA-seq to quantify NFE2L2 (NRF2) variant effects

Magdalena E Strauß, Andrew J. Waters, Holly Roberston, Timothy Brendler-Spaeth, Aleksander M. Gontarczyk, Prashant Gupta, Shikha Kataria, Daniel P. Gitterman, Tumisang Ntereke, Leah Wells, Jamie Billington, Andrew Roger Bassett, Sarah Cooper, D. Adams

Saturation-seq combines genome editing and single-cell RNA-seq to quantify variant effects on NFE2L2, accurately distinguishing pathogenic from benign variants.

bioRxiv · Jul 4, 2026 · PreprintGenomics

High-throughput phenotyping of single nucleotide variants by linking transcriptomes to genotypes in single cells

Sarah Cooper, Matthew A. Coelho, Magdalena E Strauß, Aleksander M. Gontarczyk, Qianxin Wu, Mathew J. Garnett, John C. Marioni, Andrew Roger Bassett

This study links single-cell transcriptomes to genotypes to assess the functional impact of single nucleotide variants, classifying missense variants into three categories.

Genome biology · Jan 15, 2024Peer-reviewedGenetics