Chunhai Fan

DNA-Programmed Condensate-Membrane Wetting and Cellular Internalization

This study designs DNA condensates that control their interaction with cell membranes, showing that internalization depends on a balance between adhesion and fluidity, not just affinity.

Imaging Intrinsic Stochastic Magnetic Fluctuations in Living Cells

This paper introduces BISPIN, a framework to quantify weak stochastic magnetic fluctuations in living cells, distinguishing live cells from fixed ones and mapping subcellular magnetic activity.

A reconfigurable DNA memory architecture for hierarchical data management via programmable phase transitions

This paper introduces a reconfigurable DNA memory architecture that enables hierarchical data management through programmable phase transitions, achieving high storage density and stability.

DNA-barcoded microneedle array patch enabling the profiling of in vivo spatiotemporal transcriptomics

This paper introduces aivST, a method for in vivo spatiotemporal transcriptomics using DNA-barcoded microneedles, revealing dynamic transcript expression patterns during mouse skin wound healing.

High-pressure Golgi neuronal staining for X-ray whole-brain imaging

This paper introduces a rapid high-pressure Golgi staining method for whole-brain neuronal imaging, reducing staining time from 16 days to 4 days and demonstrating applicability across multiple species.

Interwoven DNA-MOF crystals for multi-millennial data storage

This paper introduces DNA-MOF crystals for long-term data storage, achieving high density and stability over 24,000 years.

DNA framework array enables ultra-high throughput DNA synthesis

The paper introduces a DNA framework array for high-throughput DNA synthesis with single-molecule control, achieving a 4-order-of-magnitude improvement in synthesis throughput.

Cross-scale visualization of RNA dynamics in whole plants using an RNA-triggered reporting system

This paper develops an RNA-triggered fluorescence reporter system for real-time visualization of RNA dynamics across spatial scales in whole plants.

Random Sanitization in DNA information storage using CRISPR-Cas12a

The paper introduces RSDISC, a method using CRISPR-Cas12a for random sanitization of DNA-stored metadata, achieving 99.9% efficiency in degrading 28,258 oligonucleotides.