A temporally controlled sequence of X-chromosomeinactivation and reactivation defines female mouse in vitro germ cells with meiotic potential
Jacqueline Severino, Moritz Bauer, Tom Mattimoe, Niccolò Arecco, Luca Cozzuto, Patricia Lorden, Norio Hamada, Yoshiaki Nosaka, So I Nagaoka, Pauline N. C. B. Audergon, Antonio Tarruell, Holger Heyn, Katsuhiko Hayashi, Mitinori Saitou, Bernhard Payer
This study investigates X-chromosome inactivation and reactivation dynamics in female mouse PGCLCs, showing that a precise temporal sequence is critical for meiotic potential.
The EMBO Journal · May 23, 2022Peer-reviewedDevelopmental Biology