A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals
Jorge Lázaro, Maria Costanzo, Marina Sanaki-Matsumiya, Charles Girardot, Masafumi Hayashi, Katsuhiko Hayashi, Sebastian Diecke, Thomas B. Hildebrandt, Giovanna Lazzari, Jun Wu, Stoyan Petkov, Rüdiger Behr, Vikas Trivedi, Mitsuhiro Matsuda, Miki Ebisuya
The paper uses stem cell differentiation to study developmental tempo scaling across mammals and finds that segmentation clock periods correlate with phylogeny and biochemical kinetics of HES7, but not metabolic rates.
Cell stem cell · Jun 20, 2023Peer-reviewedDevelopmental Biology