Karla M. Neugebauer

The paper investigates how SRRM4 facilitates efficient co-transcriptional splicing of microexons, showing that upstream intron removal enables rapid microexon inclusion in neurons.

The paper quantifies transcriptional readthrough in CML cells after imatinib treatment and shows it precedes alternative splicing changes and resistance development.

This study investigates how intron RNA structure affects gene expression using reporter assays and machine learning, finding that base pairing significantly modulates mRNA and protein levels.

This paper describes methods for isolating and analyzing nascent RNA using long-read sequencing in budding and fission yeasts to study RNA processing and transcription dynamics.

The paper develops CoSTseq to study nascent RNA base pairing in yeast, revealing rapid folding dynamics and helicase roles in ribosome biogenesis.

The paper develops a combined microscope platform that integrates quantitative phase contrast and super-resolution fluorescence imaging for high-sensitivity visualization of sub-cellular structures and molecules in their cellular context.

The paper shows co-transcriptional splicing and 3' end cleavage are functionally linked in mammalian erythropoiesis, with splicing delays and intron retention affecting cleavage efficiency.

The paper measures the energetic costs of early zebrafish embryogenesis and finds that heat dissipation scales with plasma membrane maintenance rather than cell number.

The paper uses long-read sequencing to study nascent RNA processing in fission yeast, revealing that splicing of introns is coupled and affects mRNA levels and stability.