Arnau Iglesias

This study shows SMARCA4 mutations in T-ALL lead to chemotherapy resistance by altering chromatin remodeling at AP-1 regulatory regions, reducing stress response genes.

This study identifies a developmental program for hematopoietic stem cell (HSC) dormancy established during embryogenesis through evasion of Notch signaling, revealing a mechanism for long-term regenerative potential.

The paper analyzes patient-derived SS cells to identify transcriptomic, mutational patterns, and functional pathway alterations, finding limited pathway changes but potential for MALT1 inhibition in therapy.