GenomicsbioRxivPreprint
CRISPR/Cas9 Optimization Using Electronic Genome Mapping: Potential Role for Studying Human Genetic Disease
Lindsay Schneider Opsahl, Wentao Huang, Syndi Koltz…·John F. Thompson
This study uses electronic genome mapping to analyze how gRNA mismatches affect CRISPR/Cas9 binding specificity across the human genome, revealing key regions for on- and off-target activity.
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