Cell BiologybioRxiv
Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging
Seyed Soheil Saeedi Saravi, Benoit Pugin, Florentin Constancias…·Jürg H. Beer
This study shows that gut microbiota-dependent phenylacetic acid (PAA) increases endothelial cell senescence and impairs angiogenesis in aging, with acetate able to reverse these effects.