Michael J. Rust

An underlying bistability sets amplitude and explains temperature compensation in the cyanobacterial circadian clock

The paper identifies bistability in the cyanobacterial circadian clock as a mechanism for temperature compensation, linking it to amplitude regulation and phosphorylation dynamics.

The Phenotypic Landscape of a Circadian Clock

The paper uses a deep sequencing assay to analyze how mutations affect circadian clock phenotypes, revealing factorized oscillator properties and mutation-specific effects on period and amplitude.

Information theory for data-driven model reduction in physics and biology

This paper develops an information-theoretic framework for model reduction in physics and biology, identifying relevant variables that predict future dynamics and demonstrating its application to atmospheric flows and cyanobacteria colonies.

Optimizing Oscillators for Specific Tasks Predicts Preferred Biochemical Implementations

The paper identifies preferred biochemical implementations for oscillators by analyzing stability and cost, finding natural systems favor certain designs over artificial ones.

Bayesian Modeling Reveals Ultrasensitivity Underlying Metabolic Compensation in the Cyanobacterial Circadian Clock

The paper uses Bayesian modeling to show that ultrasensitivity in KaiC phosphorylation, driven by differential KaiA binding to ATP/ADP states, enables metabolic compensation in the cyanobacterial circadian clock.