Silvia Fré

The paper shows that mechanical sorting, driven by adhesion and contractility differences, maintains basal-luminal compartmentalization and influences lineage outcomes in glandular epithelia.

The paper uses genetic barcoding and single-cell transcriptomics to identify evolutionary trajectories in breast cancer cells, linking them to poor patient survival.

The paper identifies a conserved p63-Notch axis in multilayered epithelia and shows how context-specific modules generate functional diversity.

The paper identifies a transient population of contractile fibroblasts in the mouse mammary gland that support branching morphogenesis through recruitment from the fat pad.

This study identifies Hippo/YAP and Notch signaling coordination as essential for tissue architecture-driven cell fate decisions in bi-layered epithelia during development and regeneration.

The paper investigates Notch-induced lineage conversion in mammary basal cells using single-cell transcriptomics and shows that proliferation is essential for the transition to luminal progenitors.

The paper uses single-cell RNA-sequencing to map the differentiation trajectories of mammary stem cells and identifies spatial and molecular features of lineage commitment during mammary branching morphogenesis.

This study shows fibroblast contractility is essential for inducing mammary epithelial branching through physical contact and signaling pathways involving YAP and ERK.