Chris English

A single-cell transcriptomic atlas of the pigtail macaque lung

This paper constructs a single-cell transcriptomic atlas of the pigtail macaque lung, revealing high similarity to human lung cell types and providing a reference for studying respiratory diseases in a translational model.

Maternal Influenza A Virus Infection Induces Antiviral and Immune Dysregulation in the Placenta and Fetus Without Vertical Transmission

Maternal influenza A virus infection in pregnant pigtail macaques dysregulates placental and fetal immunity, with disease severity correlating strongly with fetal, but not placental, immune perturbations.

Characterization of Resolved, Localized, and Progressing Infections at the Maternal-Fetal Interface in a Nonhuman Primate Model

This study characterizes three infection outcomes at the maternal-fetal interface in a nonhuman primate model and identifies gene expression patterns associated with infection progression, resolution, and inflammation.

A single-cell transcriptomic atlas of the periventricular proliferative zone in the late gestation fetal brain in the pigtail macaque

The paper constructs a single-cell RNA-Seq atlas of the periventricular proliferative zone in late-gestation pigtail macaque fetal brain, revealing cell states similar to human fetal brain.

A single-cell transcriptomic atlas of the pigtail macaque placenta in late gestation

This study creates a single-cell RNA-Seq atlas of the pigtail macaque placenta in late gestation, revealing similarities to human placental cell populations.

Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate Striatum

The paper analyzes multi-modal Patch-seq data from macaque striatum to reveal morphoelectric diversity and functional specialization of neuronal cell types, highlighting primate-specific features and differences from rodents.

Human Neocortical Glutamatergic Neurons Revealed Through Multimodal Profiling

The paper integrates multimodal data to characterize human neocortical glutamatergic neurons, revealing morphoelectric properties that distinguish transcriptomic subclasses and highlight species-specific differences.

Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque

The paper identifies enhancers for spinal motor neurons and develops AAV vectors to target these cells in rodents and macaques, enabling functional studies and potential therapeutic applications.