Matthew Mallory

Neocortical long-range inhibition promotes cortical synchrony and sleep

This study identifies Sst-Chodl inhibitory neurons that promote cortical synchrony and sleep by exerting long-range inhibition during low-arousal states.

Connecting single neuron transcriptomes to the projectome in mouse visual cortex

The paper integrates transcriptomic, morphological, and electrophysiological data to define neuron types in mouse visual cortex and predict their projection targets.

Multimodal characterization of variation in neuronal types in the mouse basal ganglia

This study uses multimodal Patch-seq data to show that gene expression gradients in mouse basal ganglia neurons correlate with spatial location, physiology, and morphology.

The External Globus Pallidus is a Basal Ganglia Output Hub with Action-Specific Circuits

The paper reveals the external globus pallidus (GPe) as a basal ganglia output hub with distinct subpopulations that mediate specific behaviors through projection-specific circuits.

Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate Striatum

The paper analyzes multi-modal Patch-seq data from macaque striatum to reveal morphoelectric diversity and functional specialization of neuronal cell types, highlighting primate-specific features and differences from rodents.

Human Neocortical Glutamatergic Neurons Revealed Through Multimodal Profiling

The paper integrates multimodal data to characterize human neocortical glutamatergic neurons, revealing morphoelectric properties that distinguish transcriptomic subclasses and highlight species-specific differences.

Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level

This study integrates molecular and morphological data to classify cortical neurons and map their connectomes, revealing organizational principles of brain-wide networks at the single-cell level.

Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

The paper identifies transcriptomic and morpho-electric diversity in human neocortical layer 1 interneurons, revealing greater subclass distinction compared to mouse.

Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex

The paper uses viral labeling and Patch-seq to define morpho-electric properties of GABAergic interneurons in human neocortex, revealing functional insights and reclassifying some SST neurons into PVALB subclass.

Integrating EM and Patch-seq data: Synaptic connectivity and target specificity of predicted Sst transcriptomic types

The paper predicts MET-type identities from EM data and shows they have distinct connectivity patterns and synapse targets.

Regional and cell type-specific afferent and efferent projections of the mouse claustrum

This study maps the cell-type-specific afferent and efferent projections of the mouse claustrum using viral tracing and single-neuron reconstruction, revealing its widespread connections and regional specificity.

High-throughput analysis of dendritic and axonal arbors reveals transcriptomic correlates of neuroanatomy

The paper analyzes dendritic and axonal arbors of inhibitory neurons to identify transcriptomic correlates of neuroanatomy.

Signature morpho-electric, transcriptomic, and dendritic properties of extratelencephalic-projecting human layer 5 neocortical pyramidal neurons

The paper identifies conserved and divergent morpho-electric and transcriptomic properties of human and rodent layer 5 extratelencephalic-projecting neurons using patch-seq in human brain slices.

Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons

The paper characterizes transcriptomic and physiological properties of GABAergic cortical neurons in mice, identifying 20 interneuron met-types with consistent features across modalities.

Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons

The paper identifies transcriptomic diversity in human supragranular neurons and links it to functional specialization and disease vulnerability.