Author

Laura J. Benson

Babraham InstituteORCID 0000-0002-7239-6126Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Stephen J. ClarkiD· 2 shared Wolf ReikiD· 2 shared Álvaro Rada-IglesiasiD· 1 shared Antonio BarraliD· 1 shared Fabrizio OlmedaiD· 1 shared Felix Krüger· 1 shared Giuliano CrispatzuiD· 1 shared Joanna WysockaiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenomics

Stephen J. ClarkORCID

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2 papers

Recent·Most cited

Enhancer-associated H3K4 methylation safeguards in vitro germlinecompetence

Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, Patricia Respuela, Michaela Bartusel, Laura J. Benson, Stephen J. Clark, Kristel M. Dorighi, Antonio Barral, Magdalena Laugsch, Wilfred F. J. van IJcken, Miguel Manzanares, Joanna Wysocka, Wolf Reik, Álvaro Rada-Iglesias

The paper shows that H3K4me1 retention in enhancers supports germline competence by maintaining enhancer accessibility and responsiveness during in vitro differentiation.

Nature Communications · Oct 1, 2021Peer-reviewedGenomics

Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates

Fabrizio Olmeda, Tim Lohoff, Stephen J. Clark, Laura J. Benson, Felix Krüger, Wolf Reik, Steffen Rulands

This paper develops a framework to infer spatio-temporal processes in the nucleus from single-cell methylome data, showing feedback between DNA methylation and chromatin condensates during pluripotency exit.

bioRxiv · Dec 30, 2020 · PreprintGenomics