Miguel Manzanares

This study shows that DNA replication is not required for early mouse embryo development but is necessary for maintaining heterochromatin organization during zygotic genome activation.

This study identifies NR6A1 as a critical regulator of mammalian neural crest cell specification, formation, and survival through loss-of-function experiments and multiomic analyses.

This study shows that CTCF is essential for establishing 3D chromatin structure and regulating metabolic and protein homeostasis during early mouse development, but these functions operate independently.

This study shows pluripotency factors like OCT4 and NANOG initially repress and later enable activation of lineage specifiers, including the HoxB cluster, during early embryonic development.

The paper shows that H3K4me1 retention in enhancers supports germline competence by maintaining enhancer accessibility and responsiveness during in vitro differentiation.

The paper identifies novel enhancers and silencers linked to atrial fibrillation using an in vivo mouse reporter assay system with increased throughput.

This study investigates the role of STAG2 cohesin in heart development by analyzing Stag2-ablated mice, finding essential roles in cardiac transcriptional programs and heart tube formation.

This study identifies Nanog as a repressor of Pou3f1, which inhibits anterior neural fate during gastrulation in mouse embryos.

The paper identifies a human accelerated region in Chromosome 14q12 that enhances forebrain expansion through increased enhancer activity in transgenic mice and organoids.

This study identifies Notch's role in driving cell potency transitions during early mouse development, revealing novel targets and interactions with Hippo signaling.