Fabrizio Olmeda

The paper investigates how scaling of signaling pathways affects adult organ regeneration, finding that mismatched scaling of SHH and Wnt9a signaling prevents digit regeneration in large blastemas.

The paper shows coordinated gene expression variability reflects cell regulatory states using scRNA-seq data and machine learning.

This paper develops a framework to infer spatio-temporal processes in the nucleus from single-cell methylome data, showing feedback between DNA methylation and chromatin condensates during pluripotency exit.