Patricia Respuela

This study investigates ZIC2's role in neural development, showing it acts as a pioneer transcription factor during pluripotency exit and an enhancer activator during neural induction.

The paper shows that developmental genes and CTCF site clusters work together to enhance insulation of regulatory domains in mouse embryonic stem cells.

The paper shows that H3K4me1 retention in enhancers supports germline competence by maintaining enhancer accessibility and responsiveness during in vitro differentiation.

The paper shows that orphan CpG islands enhance the regulatory activity of poised enhancers and influence the responsiveness of target genes.