Steffen Rulands

This study identifies three temporal regimes in rejuvenation, showing that an intermediary regime enables successful rejuvenation through epigenetic plasticity and chromatin memory.

The paper shows that pre-cancerous niche remodeling by early tumour cells determines nascent tumour survival in mice.

The paper uses genetic barcoding and single-cell transcriptomics to identify evolutionary trajectories in breast cancer cells, linking them to poor patient survival.

The paper shows how DNA methylation aging emerges from a hierarchy of molecular processes across different timescales.

The paper shows coordinated gene expression variability reflects cell regulatory states using scRNA-seq data and machine learning.

The paper investigates Notch-induced lineage conversion in mammary basal cells using single-cell transcriptomics and shows that proliferation is essential for the transition to luminal progenitors.

The paper uses human pluripotent stem cells to study the epiblast development transition, revealing a transcriptional clock mechanism that governs timing and directionality through gene regulatory networks.

The paper shows that DNA methylation ageing is reflected in correlations between genomic loci, with a preference for 500 bp apart sites, and links this to PRC2-dependent H3K27me3 dilution.

The paper investigates cell lineage relationships in zebrafish fin regeneration using single-cell RNA sequencing and lineage tracing, revealing compartmentalized osteoblast and blastema contributions to bone formation.

The paper identifies lipid metabolism as a key factor in developmental pausing, showing that enhancing fatty acid oxidation extends embryo survival during mTOR inhibition.

This paper develops a framework to infer spatio-temporal processes in the nucleus from single-cell methylome data, showing feedback between DNA methylation and chromatin condensates during pluripotency exit.

The paper investigates the dynamics of adult neural stem cells in zebrafish, showing a hierarchical organization with reservoir and operational stem cells and an upstream progenitor population supporting long-term neurogenesis.

The paper identifies Lgr5+ hepatoblasts as bi-potent liver progenitors that contribute to liver development and reside at the apex of the embryonic hepatoblast hierarchy.

The paper shows that during exit from pluripotency, coexpression of DNMT3s and TETs drives genome-scale DNA methylation oscillations, with amplitude dependent on CpG density, observed both in vitro and in vivo.