Synonymous codon substitutions regulate transcription and translation of an upstream gene
Anabel Rodríguez, Gabriel S. Wright, Taylor J. Lundgren, McKenze J. Moss, Jun Li, Tijana Milenković, Paul W. Huber, Matthew M. Champion, Scott Emrich, Patricia L. Clark
The paper shows that synonymous codon substitutions in E. coli can upregulate an upstream gene through cryptic transcription, challenging the view that synonymous mutations have no phenotypic effects.
bioRxiv · Aug 5, 2022 · PreprintMolecular Biology