Farshid Guilak

This study shows leptin drives OA pain via sensory neuron reprogramming, not cartilage signaling, by analyzing mouse models and human datasets.

The paper identifies an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, explaining pain-structure discordance in obesity-associated osteoarthritis.

This study shows that knocking out Piezo1 and Piezo2 in chondrocytes protects against post-traumatic osteoarthritis structural damage and pain in mice.

This study shows that maternal high-fat/high-sugar diet affects craniofacial and dental morphology in adult offspring mice, with sex-specific and generation-persistent skeletal effects in females.

This study develops programmable gene circuits that deliver IL-1Ra in a circadian manner to protect cells from inflammation.

This paper develops a dual-responsive synthetic gene circuit that combines circadian and inflammatory signals to enable timed and enhanced therapeutic drug delivery in inflammatory arthritis.

This study shows PIEZO1 regulates collagen synthesis in hASCs based on substrate architecture, with YAP/TAZ translocation and collagen production being independent outcomes of PIEZO1 activation.

This study investigates how TRPV4 mutations affect chondrocyte differentiation and identifies altered BMP signaling as a mechanism for skeletal dysplasia.

This paper investigates how a COL6A3 mutation affects chondrocyte response to mechanical stress in a human iPSC-derived cartilage organoid model, finding reduced PCM protein binding and impaired stress response.

This paper develops a bioartificial implant using CRISPR-Cas9-engineered stem cells to deliver anti-cytokine drugs in response to inflammation, reducing arthritis severity in mice.

This paper develops a synthetic mechanogenetic gene circuit in engineered tissues that produces a therapeutic drug in response to mechanical loading.

This study identifies gene regulatory networks driving digit tip regeneration in mice, showing level-dependent differences in gene expression and tissue regrowth.

This study identifies a feedforward mechanism in osteoarthritis where IL-1-induced Piezo1 upregulation enhances mechanotransduction and contributes to cartilage damage.

This study uses scRNA-seq to analyze murine hindlimb development, identifying cellular heterogeneity and trajectories of lineage specification across embryonic stages.

The paper uses scRNA-seq and lasso regularized logistic regression to identify gene and regulatory signatures in human MSC chondrogenesis, revealing subpopulations and their differentiation potential.

This study evaluates how human mesenchymal stem cells on 3D woven scaffolds form cartilage and bone tissue in vivo and in vitro, showing that pre-culturing affects tissue type and mineralization.