GenomicsNucleic Acids ResearchPeer-reviewed
UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation
Rochelle L. Tiedemann, Joel A. Hrit, Qian Du…·Scott B. Rothbart
This study shows UHRF1 ubiquitin ligase activity and DNMT1 ubiquitin reading activity are essential for maintaining low-density CpG methylation, and their disruption leads to hypomethylation and PMD formation in cancer.
21 citations