Joel A. Hrit

This study identifies a feed-forward mechanism where UHRF1 reads and writes H3 mono-ubiquitination to maintain DNA methylation at CpG-sparse regions.

This study shows how bacterial effector RomA is regulated by host histone modifications, revealing a new layer of host-pathogen interaction through epigenetic crosstalk.

This paper identifies EZH1-dependent H3K27me1 as an adaptive chromatin barrier limiting DNMT inhibitor response in colorectal cancer and shows that dual EZH1/2 inhibition synergizes with DNMTi to enhance therapeutic efficacy.

This study shows UHRF1 ubiquitin ligase activity and DNMT1 ubiquitin reading activity are essential for maintaining low-density CpG methylation, and their disruption leads to hypomethylation and PMD formation in cancer.

This study identifies a mitotic chromatin-marking pathway that controls the asymmetric segregation of UV-induced DNA damage in human cells.

This study shows ARID1A maintains repressive H3.3 chromatin through interactions with CHD4 and ZMYND8, suppressing genes involved in cell motility and epithelial-to-mesenchymal transition in endometriotic cells.

The paper identifies an OGT-TET3 complex that regulates 5mC and 5hmC levels and XCI in female mouse embryonic stem cells.