Bradley M. Dickson

A feed-forward UHRF1 read-write mechanism supports H3 multi- mono-ubiquitination and DNA methylation maintenance at CpG-sparse regions

This study identifies a feed-forward mechanism where UHRF1 reads and writes H3 mono-ubiquitination to maintain DNA methylation at CpG-sparse regions.

Thermodynamic Insights into the WT and Y220C TP53 DBDs Reveals that the Oncogenic Y220C Variant is a Loss of Function Mutation for Zn2+-binding at Physiological Temperature

The paper investigates the thermodynamic effects of the Y220C TP53 mutation on Zn2+-binding and shows that Rezatapopt restores Zn2+-affinity through two pathways.

Molecular dynamics simulations provide insights into ULK-101 potency and selectivity toward autophagic kinases ULK1/2

This study uses molecular dynamics simulations to analyze how ULK-101 binds to ULK1/2 kinases, revealing structural features that explain its potency and selectivity.

UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation

This study shows UHRF1 ubiquitin ligase activity and DNMT1 ubiquitin reading activity are essential for maintaining low-density CpG methylation, and their disruption leads to hypomethylation and PMD formation in cancer.

Analysis of histone antibody specificity directly in sequencing data using siQ-ChIP

This paper introduces siQ-ChIP, a method to generate quantitative ChIP-seq data without spike-in normalization and shows how antibody specificity can be analyzed directly in ChIP-seq experiments.

siQ-ChIP:A reverse-engineered quantitative framework for ChIP-sequencing

The paper introduces a quantitative framework for ChIP-seq analysis that avoids the need for spike-in reagents by leveraging competitive binding during the IP step and provides a visualization technique for richer data characterization.