Alison A. Chomiak

EZH1-dependent H3K27me1 is an adaptive chromatin barrier that limits DNMT inhibitor response in colorectal cancer

This paper identifies EZH1-dependent H3K27me1 as an adaptive chromatin barrier limiting DNMT inhibitor response in colorectal cancer and shows that dual EZH1/2 inhibition synergizes with DNMTi to enhance therapeutic efficacy.

UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation

This study shows UHRF1 ubiquitin ligase activity and DNMT1 ubiquitin reading activity are essential for maintaining low-density CpG methylation, and their disruption leads to hypomethylation and PMD formation in cancer.

Nde1 is Required for Heterochromatin Compaction and Stability in Neocortical Neurons

This study identifies NDE1's role in heterochromatin compaction and stability in neocortical neurons, linking its dysfunction to neurodevelopmental and neuropsychiatric disorders.

Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

This study shows Brap loss leads to H2A ubiquitination, causing aging hallmarks and neurodegeneration in mice, with similar findings in Alzheimer's human brain tissue.

siQ-ChIP:A reverse-engineered quantitative framework for ChIP-sequencing

The paper introduces a quantitative framework for ChIP-seq analysis that avoids the need for spike-in reagents by leveraging competitive binding during the IP step and provides a visualization technique for richer data characterization.