Author

Theinmozhi Arulraj

Johns Hopkins UniversityORCID 0000-0002-7258-7512Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Aleksander S. PopeliD· 2 shared Hanwen WangiD· 2 shared Alex V. CarriD· 1 shared Anjana PunniamoorthyiD· 1 shared Anna KuchinaiD· 1 shared Atul M. DeshpandeiD· 1 shared Cesar Augusto Santa-MariaiD· 1 shared Christian DieneriD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersSystems Biology

Aleksander S. PopelORCID

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Author profile →

4 papers

Recent·Most cited

Phenotypic heterogeneity in the human gut microbiome revealed by subspecies-resolution single-cell transcriptomics

Dmitry A. Sutormin, Karl D. Gaisser, Jacqueline Haring, Anjana Punniamoorthy, Theinmozhi Arulraj, Crystal Perez, Christian Diener, Katherine Ramos Sarmiento, Alex V. Carr, Noa Rappaport, Sean M. Gibbons, Anna Kuchina

The paper develops metaSPLiT, a single-cell RNA sequencing method, to reveal sub-species functional specialization in the human gut microbiome.

bioRxiv · Jul 31, 2026 · PreprintMicrobiology

Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade

Theinmozhi Arulraj, Hanwen Wang, Atul M. Deshpande, Ravi Varadhan, Leisha A. Emens, Elizabeth M. Jaffee, Elana Judith Fertig, Cesar Augusto Santa-Maria, Aleksander S. Popel

The paper uses virtual patient models to evaluate biomarkers for predicting response to PD-1 blockade in TNBC, finding that early on-treatment biomarkers and blood-based markers offer better performance.

Proceedings of the National Academy of Sciences · Oct 28, 2024Peer-reviewedSystems Biology

Germinal centers are permissive to subdominant antibody responses

Philippe Auguste Robert, Theinmozhi Arulraj, Michael Meyer‐Hermann

The paper uses in silico simulations to show that immunodominance in germinal centers is driven by the most immunogenic antigen, but increased vaccine valence may reduce this dominance.

Frontiers in Immunology · Jan 10, 2024Peer-reviewedSystems Biology

Generating immunogenomic data-guided virtual patients using a QSP model to predict response of advanced NSCLC to PD-L1 inhibition

Hanwen Wang, Theinmozhi Arulraj, Holly H. C. Kimko, Aleksander S. Popel

The paper uses a QSP model to generate virtual patients for NSCLC and predicts response to PD-L1 inhibition using immunogenomic data.

npj Precision Oncology · Jun 8, 2023Peer-reviewedSystems Biology